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Amílcar Falcão Selected Research

Drug Resistant Epilepsy

6/2023Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy.
8/2022Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients.
9/2021Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats.
1/2021A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration.
6/2019Nose-to-brain delivery of levetiracetam after intranasal administration to mice.
1/2019ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches.
10/2018In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.
1/2018Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

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Amílcar Falcão Research Topics

Disease

20Epilepsy (Aura)
08/2022 - 07/2007
15Neoplasms (Cancer)
11/2023 - 04/2016
13Parkinson Disease (Parkinson's Disease)
03/2020 - 01/2008
10Seizures (Absence Seizure)
06/2022 - 08/2010
8Drug Resistant Epilepsy
06/2023 - 01/2018
4Breast Neoplasms (Breast Cancer)
10/2021 - 12/2017
4Obesity
06/2019 - 01/2014
3Infections
02/2023 - 01/2017
3Rhinosinusitis
01/2018 - 01/2017
3Bipolar Disorder (Manic Depressive Psychosis)
03/2015 - 07/2007
2Anhedonia
03/2024 - 12/2023
2Neoplasm Metastasis (Metastasis)
12/2022 - 04/2021
2Inflammation (Inflammations)
10/2022 - 01/2019
2Coronary Disease (Coronary Heart Disease)
07/2020 - 05/2016
2Stroke (Strokes)
03/2020 - 10/2019
2Venous Thromboembolism
03/2020 - 10/2019
2Atrial Fibrillation
03/2020 - 10/2019
1Alzheimer Disease (Alzheimer's Disease)
01/2023
1Neuroinflammatory Diseases
01/2023
1Osteosarcoma (Osteogenic Sarcoma)
12/2022
1Neoplasm Micrometastasis
12/2022
1Liver Neoplasms (Liver Cancer)
12/2022
1Chronic Disease (Chronic Diseases)
10/2022
1Status Epilepticus (Complex Partial Status Epilepticus)
06/2022
1Myalgia
04/2022
1Hepatocellular Carcinoma (Hepatoma)
10/2021
1Central Nervous System Diseases (CNS Diseases)
08/2021
1Adenocarcinoma of Lung
02/2021
1Cystic Fibrosis (Mucoviscidosis)
12/2020
1Inborn Genetic Diseases (Disease, Hereditary)
12/2020
1Generalized Epilepsy
10/2020
1Glioblastoma (Glioblastoma Multiforme)
10/2020
1Unconsciousness (Loss of Consciousness)
05/2020
1Neurodegenerative Diseases (Neurodegenerative Disease)
03/2020

Drug/Important Bio-Agent (IBA)

16Anticonvulsants (Antiepileptic Drugs)IBA
06/2023 - 01/2013
10Levodopa (L Dopa)FDA LinkGeneric
01/2017 - 01/2008
8Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
01/2017 - 01/2008
8opicaponeIBA
01/2017 - 01/2012
7eslicarbazepine acetateIBA
03/2015 - 07/2007
4VaccinesIBA
11/2023 - 01/2017
4perampanelIBA
06/2023 - 08/2021
4Levetiracetam (Keppra)FDA LinkGeneric
08/2022 - 06/2019
4Member 1 Subfamily B ATP Binding Cassette TransporterIBA
09/2021 - 12/2017
3Anti-Bacterial Agents (Antibiotics)IBA
02/2023 - 01/2017
3rufinamideFDA Link
08/2022 - 08/2019
3FlavonoidsIBA
09/2021 - 08/2017
3LacosamideFDA Link
06/2021 - 01/2021
3Proteins (Proteins, Gene)FDA Link
01/2021 - 12/2017
3LipidsIBA
10/2020 - 05/2016
3nebicaponeIBA
01/2012 - 01/2008
2Norepinephrine (Noradrenaline)FDA LinkGeneric
01/2023 - 05/2018
2Dopamine (Intropin)FDA LinkGeneric
01/2023 - 05/2018
2Peptides (Polypeptides)IBA
01/2023 - 10/2020
2Therapeutic UsesIBA
10/2022 - 02/2013
2Anthocyanins (Anthocyanin)IBA
10/2022 - 07/2021
2stiripentolIBA
08/2022 - 08/2021
2PyrogallolIBA
04/2022 - 07/2021
2catechol (pyrocatechol)IBA
04/2022 - 07/2021
2SilymarinIBA
09/2021 - 01/2018
2Zonisamide (Zonegran)FDA LinkGeneric
01/2021 - 03/2020
2AnticoagulantsIBA
03/2020 - 10/2019
2Dosage Forms (Dosage Form)IBA
06/2019 - 06/2011
2Lamotrigine (Lamictal)FDA LinkGeneric
05/2018 - 05/2017
2Carbamazepine (Tegretol)FDA LinkGeneric
05/2017 - 08/2010
2Voltage-Gated Sodium ChannelsIBA
08/2009 - 07/2007
1Sucrose (Saccharose)IBA
03/2024
1Sertraline (Zoloft)FDA LinkGeneric
12/2023
1Amikacin (A.M.K)FDA LinkGeneric
02/2023
1CannabinoidsIBA
01/2023
1Nerve Growth Factors (Neurotrophins)IBA
01/2023
1Serotonin (5 Hydroxytryptamine)IBA
01/2023
1Amyloid beta-PeptidesIBA
01/2023
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2023
1Glutamic Acid (Glutamate)FDA Link
01/2023
11- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA
12/2022
1Hormones (Hormone)IBA
12/2022
1Indocyanine Green (Cardio-Green)FDA LinkGeneric
12/2022
1Chelating AgentsIBA
12/2022
1Copper-64IBA
12/2022
1D-luciferinIBA
12/2022
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
10/2021
1Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2021
1Epidermal Growth Factor (EGF)IBA
10/2021
1ezogabine (retigabine)IBA
08/2021
1OximesIBA
05/2021
1GelsIBA
02/2021
1NivolumabIBA
01/2021
1Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
12/2020
1Biomarkers (Surrogate Marker)IBA
10/2020
1CholesterolIBA
07/2020
1Propofol (Diprivan)FDA LinkGeneric
05/2020
1AntigensIBA
02/2020
1Analgesics (Analgesic Drugs)IBA
01/2020
1Serum-Free Culture MediaIBA
01/2020
1AntioxidantsIBA
01/2020

Therapy/Procedure

17Therapeutics
01/2023 - 06/2010
4Immunotherapy
01/2021 - 01/2017
3Drug Therapy (Chemotherapy)
02/2023 - 04/2013
3Intranasal Administration
01/2021 - 01/2017
1Precision Medicine
10/2021